R&D Systems

Human/Mouse FoxP3 Antibody

品名：: Human/Mouse FoxP3 Antibody

货号：: RD3210

产品品牌：: RD

价格：: 快速询价 QQ索要说明书电话：15061608254

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Product Details

Species Reactivity

Human, Mouse
Specificity

Detects human FoxP3 in direct ELISAs. Detects human and mouse FoxP3 in flow cytometry.
Source

Recombinant Monoclonal Rabbit IgG Clone # 1054C
Purification

Protein A or G purified from cell culture supernatant
Immunogen

E. coli-derived recombinant human FoxP3
Met1-Leu71
Accession # Q9BZS1
Formulation

Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Label

Unconjugated

Preparation and Storage

Human FoxP3 is a 47 kDa member of the P subclass of the FOX (forkhead box) family of transcription factors. It contains a Leu-rich repeat, a C2H2 zinc finger region, and a C-terminal FKH (fork head), DNA-binding domain. Three isoforms for FoxP3 have been reported. All three isoforms share the sequence used as the immunogen. FoxP3 directly associates with NFAT and NFkB, suppressing their activity in CD4+ T cells. In human, FoxP3 is found in CD4+, CD8+ and CD4+CD25+T cells. Over the region used for immunization of the amino acid sequence, mouse FoxP3 is 83% to 88% identical to rat, human, canine, and bovine FoxP3.

Long Name:

Forkhead Box P3
Entrez Gene IDs:

50943 (Human); 20371 (Mouse)
Alternate Names:

AIID; AIIDMGC141961; DIETER; forkhead box P3; Forkhead Box Protein P3; FoxP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked; IPEX; JM2; MGC141961; MGC141963; PIDX; PIDXMGC141963; SCURFIN; XPID; XPIDpolyendocrinopathy, enteropathy, X-linked

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